That's what I do. Just program the toggles as needed. I use #1 for the receiver, and #2 for Bluetooth for my MacBook. I leave #3 blank. Use the Logitech Unifying software to add/remove devices as needed - I added a T650 trackpad to the receiver but hardly use it.
I suspect you can also use up to 3 receivers, but I haven't gone down that route.
Since the Unifying receiver goes into my monitor, and the monitor is connected via USB-C, I can also just leave it in the monitor and transfer the USB-C connection to my MacBook. It will work too.