First of all, it's important to make a nomination, and to update it as/when appropriate. Otherwise there are extra probate costs required, and those costs are best avoided.
In my view, the Enhanced Nomination Scheme (ENS) is only useful to the extent it can top up a surviving CPF member's Medisave Account when that member is hitting the CPF Annual Limit and cannot effectively do it him/herself. The ENS is not counted toward the CPF Annual Limit. If a deceased CPF member's CPF funds are paid out in cash to a survivor (or survivors), they can then turn around and top up their own Special Account or Retirement Account. If they have not yet reached the Full Retirement Sum (FRS), they might even qualify for tax relief when they do that. So the ENS doesn't seem too exciting to me in that sense, unless I'm missing something.
If you think the survivor won't be "smart" and might do something crazy, like blow all the inherited cash at a casino, then the ENS begins to make more sense.