Those visiting Osaka/Kyoto:
i just came back 2 months ago, had a beautiful cherry blossom holiday there.
Mainly if you are into shopping, Tokyo offers more but you can get to shop at Shinsaibashi area in Osaka, can find the typical drugstores, Daiso, Uniqlo, Tokyu Hands and street shops here. Umeda has malls for shopping too. These are the main places people usually go for shopping. There are other malls like HEP-5 etc, it's up to your time and preference to include these too.
Basically, Osaka is another city in Japan, more laid back than Tokyo.
For sightseeing and entertainment, you can visit Universal Studios, theirs is bigger and has more rides and activities than SG! The Aquarium is also very popular. Osaka castle is also a good place for sightseeing esp during spring or autumn.
i stayed at NIKKO HOTEL in Osaka, near Shinsaibashi, location is very good for shopping and eating. It's a small standard but clean hotel and moderately priced. I highly recommend this hotel. It is also very near the train station, less than a minute walk.
Osaka to Kyoto take around plus minus an hour to reach, including the travelling time to train station, buying tickets, walking up and down finding the right directions etc.
Kyoto is a totally beautiful place, if you're into culture, you may like to spend more days here and slowly visit all the beautiful shrines and temples.
A must visit would be Kiyomizudera temple, Sanjusangendo, Hei An shrine, Fushimi Inari.
I love Fushimi Inari, the film Memoirs of a Geisha was filmed there too.
I stayed around GION area in Kyoto and loved that area because it was near Maruyama Park and they had a food carnival there at that time when i was staying cuz it was spring. It was a short walk to restaurants, Pachinko Parlours and you can also walk to their main shopping area called Kawaramachi/Shijo.
Shopping is not as extensive here than in Osaka and Tokyo though.
Please read my blog as i have more detailed info on Japan there.
Have been there 3 times, i have yet to blog about my 3rd trip there but will do so very very soon, meanwhile, hope my travelogue on Japan during my 1st and 2nd trip will help you guys who are going there.