Interesting......... zhun or not i am not sure, not pro in this.
But i came across various vids on medical/scientific experts (professors etc) stating that at most cancers are 55% genetic. Rest is epigenetics, environment.....
Yes, the scientific community increasingly views cancer as a metabolic disease,
not solely a genetic one. While cancer involves genetic mutations, this view suggests that a primary disturbance in cellular energy metabolism, particularly in the mitochondria, is the root cause. Cancer cells rewire their metabolism to fuel their growth by creating new energy production pathways to meet the high demands of continuous cell division.
How cancer is a metabolic disease
- Primary metabolic disturbance:
Emerging evidence points to a disturbance in energy metabolism as the initial event in cancer development, with genetic mutations being a downstream consequence.
- Mitochondrial dysfunction:
Abnormalities in the structure and function of mitochondria are linked to these initial metabolic disturbances.
- Warburg effect:
Cancer cells rely on fermentation to produce energy, even in the presence of oxygen, a process known as the Warburg effect. This is a primitive energy source that creates lactic acid and is less efficient than oxidative phosphorylation but provides building blocks for rapid growth.
- Fueling growth:
This dysregulated metabolism provides the necessary energy and building blocks for the high demands of continuous cell growth and division.
- Genetic mutations as a consequence:
The prolonged reliance on these inefficient metabolic pathways can lead to genome instability and the mutations that are characteristic of cancer.
Bonus (SG data)
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