Do this type of Cholesterol need to take med?

[The_King]

Am keeping your posts separated between 2rm and cholesterol.

Your triglycerides is lower than mine. I'm at 93mg/dl. Down from 103 a year ago.
My total cholesterol is 413mg/dl

The reason I asked if you have taken insulin test is to confirmed that your insulin is probably really high. AND you are still injecting insulin.

Where did you had your blood tests done?

Done at poly.

Also insulin, apo etc maybe in sep or oct

Will update when it I done it.

Maybe colonscopy end of the yr

 

[asymmetric]

I am taking rosuvastatin...

TC: 6.81 mmol/L (< 5.2)
LDL: 4.56 mmol/L (< 2.6)
HDL: 1.84 mmol/L (> 1.6)
Triglycerides: 0.91 (< 1.7)


Rosuvastatin belongs to a group of medicines called HMG-CoA reductase inhibitors, or statins. It works by blocking an enzyme that is needed by the body to make cholesterol, so this reduces the amount of cholesterol in the blood.

 

[rogze79]

Is cholesterol really that fearsome that one have to take drugs to suppress our body from making it naturally?

It is a raw material/precursor to so many processes in our body. TESTOSTERONE. Vitamin D3. Cell membrane. Cell signaling..

 

[standarture]

Is cholesterol really that fearsome that one have to take drugs to suppress our body from making it naturally?

It is a raw material/precursor to so many processes in our body. TESTOSTERONE. Vitamin D3. Cell membrane. Cell signaling..

Depends. It is not guaranteed to cause plague buildup or heart disease. It is just reported to have a link. No medical study will ever use the word "definitely".

 

[rarenick]

Is cholesterol really that fearsome that one have to take drugs to suppress our body from making it naturally?
It is a raw material/precursor to so many processes in our body. TESTOSTERONE. Vitamin D3. Cell membrane. Cell signaling..

Our body is not perfect and sometimes get confused over things, that's why u see some people got autoimmune diseases. There are also cases of abuse like taking too much sweet things, becoming insulin resistant and then get diabetes. So when you say let the body do its own work, this may not be the best thing for people who don't know how to take care of themselves or didn't realise that they overlooked something. Best bet is to do the correct types of checkups. Many youtube videos by cardiologists suggested some types of test, and didn't rely on the usual LDL HDL profile. You are also right in some ways or other.

 

[rogze79]

Depends. It is not guaranteed to cause plague buildup or heart disease. It is just reported to have a link. No medical study will ever use the word "definitely".

It's not causal.

 

[Ultima Online]

Is cholesterol really that fearsome that one have to take drugs to suppress our body from making it naturally?

It is a raw material/precursor to so many processes in our body. TESTOSTERONE. Vitamin D3. Cell membrane. Cell signaling..

Mevalonate hypothesis vs Cholesterol hypothesis

Search Labs | AI Overview

The mevalonate and cholesterol hypotheses offer contrasting views on the development of atherosclerosis (plaque buildup in arteries), a major risk factor for heart disease. The cholesterol hypothesis posits that high levels of cholesterol in the blood directly cause atherosclerosis. The mevalonate hypothesis, however, suggests that cholesterol is not the primary culprit. Instead, it proposes that the mevalonate pathway, a crucial metabolic pathway for cholesterol synthesis, plays a more complex role, potentially contributing to inflammation and other factors that lead to plaque buildup.

Here's a more detailed breakdown:
Cholesterol Hypothesis:

• Core idea:
  Elevated blood cholesterol, particularly LDL cholesterol, directly contributes to the formation of atherosclerotic plaques.
  
  
• Mechanism:
  High cholesterol levels lead to cholesterol deposition in artery walls, triggering an inflammatory response and the formation of plaques.
  
  
• Evidence:
  Studies show a correlation between high blood cholesterol levels and increased risk of heart disease.
  
  
• Criticism:
  Some argue that it doesn't fully explain why some individuals with high cholesterol don't develop significant atherosclerosis, while others with seemingly normal cholesterol levels do.

Mevalonate Hypothesis:

• Core idea:
  The mevalonate pathway, which is involved in cholesterol synthesis, is implicated in the development of atherosclerosis through various mechanisms, not solely through cholesterol levels.
  
  
• Mechanism:
  The mevalonate pathway produces not only cholesterol but also other important molecules called isoprenoids, which can influence inflammation, cell growth, and other processes involved in plaque formation.
  
  
• Evidence:
  Research suggests that inhibiting the mevalonate pathway, even without directly targeting cholesterol, can have beneficial effects on cardiovascular health.
  
  
• Explanation for some findings:
  The mevalonate hypothesis provides a potential explanation for why cholesterol-lowering drugs can be effective in preventing cardiovascular disease, even if cholesterol itself is not the sole cause.

Key Differences:

• Causality:
  The cholesterol hypothesis focuses on cholesterol as a direct causal factor, while the mevalonate hypothesis suggests that the pathway itself, with its diverse products, plays a more significant role.
• Complexity:
  The mevalonate hypothesis acknowledges the complexity of cellular processes and the interconnectedness of various metabolic pathways, while the cholesterol hypothesis is more focused on a single molecule.

In essence, the mevalonate hypothesis offers a more nuanced view of the relationship between cholesterol, metabolism, and cardiovascular disease, suggesting that it's not just about the cholesterol level in the blood, but also about how the body synthesizes and utilizes cholesterol and related molecules.


Search Labs | AI Overview

The mevalonate pathway hypothesis suggests that the true cause of atherosclerosis, and potentially other diseases, lies in the inflammatory response and subsequent free radical production within endothelial cells, rather than solely elevated cholesterol levels. It proposes that inflammatory factors stimulate this pathway, leading to the formation of free radicals and ultimately oxidized cholesterol, a key factor in plaque buildup. This shifts the focus from cholesterol reduction as the primary therapeutic target to addressing the underlying inflammatory processes and free radical production.

Here's a more detailed breakdown of the key takeaways:

1. Cholesterol is not necessarily the primary culprit: While high cholesterol levels are correlated with cardiovascular disease, the mevalonate hypothesis suggests that cholesterol itself may not be the direct cause of atherosclerosis.

2. Inflammation as a driver: The hypothesis emphasizes that inflammation within endothelial cells, the cells lining blood vessels, triggers the mevalonate pathway.

3. Free radicals as mediators: The activated mevalonate pathway in endothelial cells produces free radicals, which then contribute to the oxidation of cholesterol.

4. Oxidized cholesterol as a key player: Oxidized cholesterol is a major component of atherosclerotic plaques, and the mevalonate hypothesis suggests that its formation, driven by free radicals, is a critical step in the disease process.

5. Therapeutic implications: The hypothesis suggests that strategies to reduce inflammation and free radical production, rather than just lowering cholesterol, might be more effective in preventing and treating atherosclerosis.

6. Statins and the mevalonate pathway: Statins, commonly used to lower cholesterol by inhibiting HMG-CoA reductase (an enzyme in the mevalonate pathway), may have broader effects beyond cholesterol reduction, impacting the production of other molecules involved in inflammation and cell signaling.

7. Potential impact on other diseases: The mevalonate pathway is involved in various cellular processes, and disruptions to this pathway, potentially due to inflammation or genetic factors, could contribute to other diseases, including some neurological conditions.

In essence, the mevalonate hypothesis proposes a more nuanced understanding of atherosclerosis, highlighting the role of inflammation and free radicals in the disease process and suggesting that a broader approach to treatment may be needed.

 

[charliebrown]

any one success reverse ur cholestrol not by taking cholestrol med but by diet change?

 

[rogze79]

Our body is not perfect and sometimes get confused over things, that's why u see some people got autoimmune diseases. There are also cases of abuse like taking too much sweet things, becoming insulin resistant and then get diabetes. So when you say let the body do its own work, this may not be the best thing for people who don't know how to take care of themselves or didn't realise that they overlooked something. Best bet is to do the correct types of checkups. Many youtube videos by cardiologists suggested some types of test, and didn't rely on the usual LDL HDL profile. You are also right in some ways or other.

I'm afraid you got things mixed up.

There's a huge difference between the body maintaining a homeostasis state and the mouth taking in food/drugs due to limited/lack of knowledge/misguided advice.

Autoimmune issue is caused by intestinal permeability. Not because the body doesn't know what to do. It's what is being stuffed into the mouth mindlessly.

 

[rogze79]

any one success reverse ur cholestrol not by taking cholestrol med but by diet change?

Why would you wanna do that? Just let your body do it's job

 

[rarenick]

any one success reverse ur cholestrol not by taking cholestrol med but by diet change?

I'm about there. Few years of elevated LDL at high level. During one of the visits to polyclinic, I was first time prescribed with low dosage statin. Took medication for 2 weeks then decided not to take anymore. About 3 weeks before next check up, I realised that it's not my diet problem but other things like stress and lack of sleep. Made lifestyle changes and my LDL dropped form high to a moderate or borderline high level. With this improvement, I was allowed not to take statin. Now I just patiently wait for my next appointment to see if my new method works.

 

[charliebrown]

I'm about there. Few years of elevated LDL at high level. During one of the visits to polyclinic, I was first time prescribed with low dosage statin. Took medication for 2 weeks then decided not to take anymore. About 3 weeks before next check up, I realised that it's not my diet problem but other things like stress and lack of sleep. Made lifestyle changes and my LDL dropped form high to a moderate or borderline high level. With this improvement, I was allowed not to take statin. Now I just patiently wait for my next appointment to see if my new method works.

dunno sleep and cholestrol levels are related. tot all about wat u put in ur month.

 

[rarenick]

dunno sleep and cholestrol levels are related. tot all about wat u put in ur month.

My own understanding:

Lack sleep, over exercise, work stress = high cortisol = high LDL

Lack muscles, high sugar, high insulin resistance = high LDL

High saturated fats, trans fat = high LDL

If u are lazy, drink some evoo. Will help but at your own risk. Drink in moderation (up to 20 ml per day).

 

[rogze79]

I'm about there. Few years of elevated LDL at high level. During one of the visits to polyclinic, I was first time prescribed with low dosage statin. Took medication for 2 weeks then decided not to take anymore. About 3 weeks before next check up, I realised that it's not my diet problem but other things like stress and lack of sleep. Made lifestyle changes and my LDL dropped form high to a moderate or borderline high level. With this improvement, I was allowed not to take statin. Now I just patiently wait for my next appointment to see if my new method works.

Ah..now you see that your body makes what it needs. Dietary cholesterol doesn't really impact our cholesterol levels. Body makes more than 80%.

My own understanding:

Lack sleep, over exercise, work stress = high cortisol = high LDL

Lack muscles, high sugar, high insulin resistance = high LDL

High saturated fats, trans fat = high LDL

If u are lazy, drink some evoo. Will help but at your own risk. Drink in moderation (up to 20 ml per day).

LDL, HDL, cholesterol is the same thing isn't it? Same chemical formula. C27H46O

Ldl,hdl are lipoproteins that transport cholesterol and triglycerides around.

Want to lower cholesterol? Go plant based/vegan/vegetarian

 

[rarenick]

Ah..now you see that your body makes what it needs. Dietary cholesterol doesn't really impact our cholesterol levels. Body makes more than 80%.
LDL, HDL, cholesterol is the same thing isn't it? Same chemical formula. C27H46O
Ldl,hdl are lipoproteins that transport cholesterol and triglycerides around.
Want to lower cholesterol? Go plant based/vegan/vegetarian

I don't see the link u are trying to make about body makes what it needs from the sharing of my own understanding.

Nowadays I don't restrict my diet alot. I still eat red meat and drink animal milk (although mostly soy milk). I doubt I will get enough nutrition from vegan diet because I don't cook and more than half the time eat outside.

 

[rogze79]

I don't see the link u are trying to make about body makes what it needs from the sharing of my own understanding.

Nowadays I don't restrict my diet alot. I still eat red meat and drink animal milk (although mostly soy milk). I doubt I will get enough nutrition from vegan diet because I don't cook and more than half the time eat outside.

In your own words.

"I realised that it's not my diet problem but other things like stress and lack of sleep. Made lifestyle changes and my LDL dropped form high to a moderate or borderline high level."

This is what I meant. Your body will make what is needed.

You are right about the insufficient nutrition from a vegan diet unless you are strategic about supplements. Dunn worry about saturated fats from animal food. It doesn't make one fat nor inflamed the body.

General blood markers like esr and hscrp tells something about inflammation in the body.

 

[rarenick]

In your own words.
"I realised that it's not my diet problem but other things like stress and lack of sleep. Made lifestyle changes and
my LDL dropped form high
to a moderate or borderline high level."
This is what I meant. Your body will make what is needed.
You are right about the insufficient nutrition from a vegan diet unless you are strategic about supplements. Dunn worry about saturated fats from animal food. It doesn't make one fat nor inflamed the body.
General blood markers like esr and hscrp tells something about inflammation in the body.

Now I understand. Basically less stress less cortisol, then body won't create unnecessary LDL. Thank you. Everything makes sense.

Is always the user problem, not the body problem. (I'm very layman, no medical lingos)

 

[Checkyrmed]

Is always the user problem, not the body problem. (I'm very layman, no medical lingos)

Insulin resistance is linked to elevated levels of Apolipoprotein B (ApoB). Increased ApoB concentrations are strongly associated with greater degrees of insulin resistance and omega-6 intake.