The effect of ratio of omega 3 to 6 is not limited to prostaglandins. Fatty acids are incorporated into our cell membrane. ALA Omega 3 will increase fluidity and flexible e.g. reduce blood pressure. The increased fluidity could made receptors more mobile e.g. increase insulin sensitivity.
The risk of high intake of fish oil capsules I have already mentioned. High seafood intake also comes with the risk of consuming too much heavy metals and pollutants like PCB etc.
Cell membranes require a balanced mix of saturated and unsaturated fatty acids to maintain both fluidity and stability. Relying too heavily on unsaturated fats can make the membrane overly fluid and permeable, leading to unintended leakage of ions and small molecules. This excessive fluidity also reduces mechanical robustness, making cells more susceptible to physical stress. Crucially, unsaturated fatty acids are prone to oxidation, generating toxic by‑products that compromise membrane integrity and overall cell health.
An overabundance of unsaturated lipids can disrupt specialized membrane microdomains known as lipid rafts, which are vital for proper signaling and protein function. Changes in membrane thickness and lateral pressure can impair receptor and enzyme activity, altering critical cellular processes. In epithelial barriers, such as the gut lining or blood–brain barrier, overly fluid membranes may weaken tight junctions, increasing vulnerability to pathogens and toxins. Thus, while unsaturated fats are essential, they must be balanced with saturated fats and cholesterol to ensure optimal membrane function and cellular resilience.
The main takeaway is oxidation from the unsaturated fat: the last thing you want is a cell membrane that’s easily damaged by oxidative stress,your cell membranes must resist oxidative damage to protect your cells.