I came across a medical study some time ago that mentions drinking too much coffee can increase cholesterol levels due cafestol. This only happens in non filtered coffee. Apparently filter coffee does not have this effect cos the paper prevents cafestol from getting into the cup.
2012 harvard health letter
What is it about coffee? - Harvard Health Publications
But upon closer inspection, the bad news turned out to be not so bad, because the cholesterol-raising effect seems to be limited to coffee that hasn't been filtered, which includes Turkish coffee, coffee brewed in a French press, and the boiled coffee consumed in Scandinavia.
The cholesterol-raising ingredients in coffee are oily substances called diterpenes, and the two main types in coffee are cafestol (pronounced CAF-es-tol) and kahweol (pronounced KAH-we-awl). They are present either as oily droplets or in the grounds floating in the coffee. But a paper filter traps most of the cafestol and kahweol, so coffee that's been filtered probably has little, if any, effect on cholesterol levels.
The best evidence is for paper filters, but an interesting study published in 2011 showed that filtering methods used in Singapore (the so-called sock method, which uses a cotton-nylon cloth) and India (metal mesh) were also effective at trapping cafestol.
Espresso contains more cafestol and kahweol than paper-filtered coffee, but because it is consumed in smaller amounts, it may not have much of an effect on people's LDL level.
same doc from Harvard
http://www.hsph.harvard.edu/nutritionsource/coffee/
It’s best to brew coffee with a paper filter, to remove a substance that causes increases in LDL cholesterol.
this talks about extraction methods and yields by University of Nottingham
http://www.sciencedirect.com/science/article/pii/S0963996912002360
Roasting time and choice of brew mechanism impact in-cup delivery of cafestol with French press, boiled coffee and Turkish preparation methods producing higher cafestol concentrations than the mocha preparation method. Higher roasting times led to a 42% reduction in cafestol concentration on a concentration basis within the brews.
The extraction yield of cafestol from R&G coffee is dependent both on the choice of brew mechanism and roasting time, with lighter roast coffee brews having a greater cafestol extraction yield and darker roast coffee brews having a lower cafestol extraction yield.
someone took the time to compiled a a list of studies. one states coffee rich in diterpenes cafestol and kahweol does not affect serum concentrations of liver aminotransferases and lipids. however they still recommend patients to drink filtered coffee. another states "Filtering removed more than 80% of the lipid-soluble substance that was present in boiled coffee"
http://coffeegeek.com/files/371/Cholesterol.doc
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