High cholesterol

Checkyrmed

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While it is true that there are cases where LDL levels do not match perfectly with ApoB or Lp(a) values, this discrepancy does not undermine the key role of insulin resistance in cardiovascular risk. ApoB remains a more precise measure of the total atherogenic particles, and Lp(a) serves as an independent risk factor. However, both markers are heavily influenced by metabolic health since insulin resistance alters lipoprotein metabolism, leading to more small, dense LDL particles and increased systemic inflammation.

Focusing solely on ApoB and Lp(a) without considering metabolic factors provides an incomplete risk profile. For example, an individual with low LDL but high ApoB still faces significant risk due to an excess of atherogenic particles driven by underlying metabolic dysfunction. Conversely, high LDL with favorable ApoB levels might suggest a predominance of larger, less harmful LDL particles, yet this does not guarantee protection if insulin resistance, inflammation, or other risk factors are present. A comprehensive risk assessment must integrate these markers with metabolic indicators for an accurate evaluation.

Insulin resistance increases the liver's production of very low density lipoproteins (VLDL) by promoting the release of free fatty acids. This results in an overproduction of VLDL particles, which carry ApoB, and as these particles are metabolized into low density lipoproteins (LDL), overall ApoB levels rise and contribute to a more atherogenic profile. In contrast, Lp(a) levels are largely determined by genetics, and while insulin resistance may slightly affect its production or clearance, its influence on Lp(a) is much less pronounced than on ApoB.

Additionally, replacing saturated fat in the diet with protein, carbohydrates, or unsaturated fat has been shown to increase Lp(a) levels by approximately 10 to 15%. This dietary change leads to a measurable rise in Lp(a), a factor linked to cardiovascular risk.
 
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rarenick

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Why I often read on products that say they lower blood cholesterol n help to prevent coronary heart diseases but most of them never mention stroke?
 

rogze79

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Stroke patients were also OK initially. Just saying.

ApoB and Lp(a) tests are not expensive.

YouTube videos ?

Avoid those keto freaks channels.

1 trustworthy channel to watch is Nutrition Made Simple by Dr Gil Carvalho.
Btw, keep an open mind.

Just because you are primarily a plant based ideologue obsessing over a plant based Dr/phd without clinical experiences or published papers/studies doesn't mean any other diets are bad.

Maybe you want to tell us what are some of the keto freaks channels you are referring to?

What's the keto diet? What's ketosis? LCHF?

Can one thrive on a plant based/vegan/vegetarian diet? Can a baby/toddler/kid be on these diets?
 
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Mecisteus

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Just saw a few seconds of the video.

Mostly about attacking the character and being personal. 😂

Dr Gil Carvalho discussion usually revolves around scientific papers only. Yes if you don't believe in things like double blind RCT publications, then don't listen to him.
 

Mecisteus

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Btw, keep an open mind.

Just because you are primarily a plant based ideologue obsessing over a plant based Dr/phd without clinical experiences or published papers/studies doesn't mean any other diets are bad.

Maybe you want to tell us what are some of the keto freaks channels you are referring to?

What's the keto diet? What's ketosis? LCHF?

Can one thrive on a plant based/vegan/vegetarian diet? Can a baby/toddler/kid be on these diets?
I don't know where did you get the idea of me WFPB.

I eat a balanced diet.

By the way, keto is the worst diet when it comes to atherosclerosis. Don't believe my word. Post this keto in r/cholesterol.
 

rogze79

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I don't know where did you get the idea of me WFPB.

I eat a balanced diet.

By the way, keto is the worst diet when it comes to atherosclerosis. Don't believe my word. Post this keto in r/cholesterol.
You mentioned before that you are primarily plant based with the exception of some meat here and there. It resonate with me because I was eating similar for a decade.

While forums are places for general knowledge, one can raise the bar by going to specialised sources.

To the doctors with decades of clinical experiences or the scientists with relevant research and published papers. It is more helpful than just the academics or the common Joes.

Is plant based really that ideal? And you did not addressed if the pbwf is ideal for kids.

And What's ketosis?
 
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Checkyrmed

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You mentioned before that you are primarily plant based with the exception of some meat here and there. It resonate with me because I was eating similar for a decade.

While forums are places for general knowledge, one can raise the bar by going to specialised sources.

To the doctors with decades of clinical experiences or the scientists with relevant research and published papers. It is more helpful than just the academics or the common Joes.

Is plant based really that ideal? And you did not addressed if the pbwf is ideal for kids.

And What's ketosis?
Many people starting a ketogenic diet often fall into common pitfalls, such as consuming excessive protein, relying on fast or fried foods, and failing to include enough healthy fats. However, reducing carbohydrates and increasing quality fats while maintaining a balanced calorie intake can improve insulin sensitivity.
 
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rogze79

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Many people starting a ketogenic diet often fall into common pitfalls, such as consuming excessive protein, relying on fast or fried foods, and failing to include enough healthy fats. However, reducing carbohydrates and increasing quality fats while maintaining a balanced calorie intake can improve insulin sensitivity.
Yeah. Many ppl forget that eggs contains similar amount of fats and proteins.

And eggs are the cheapest and most nutritious food one can get. The fatty beef ,meats with skin on and sardines in water. Not forgetting the grass fed butter and some evoo.

Yet, these food have been demonized. Ppl thought that eating fatty stuff like these makes one fat. It doesn't. Been eating these for the last couple of years. And doubled down by halving my only carbs, which is my own baked sourdough bread.

The fats are getting the blame for what the carbs did.
 

Ironside

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Why I often read on products that say they lower blood cholesterol n help to prevent coronary heart diseases but most of them never mention stroke?
Stroke got at least tyre different types. Those with super low LDL level has higher risk for one type of stroke.
 

Ironside

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Many people starting a ketogenic diet often fall into common pitfalls, such as consuming excessive protein, relying on fast or fried foods, and failing to include enough healthy fats. However, reducing carbohydrates and increasing quality fats while maintaining a balanced calorie intake can improve insulin sensitivity.
Fried food will be the killer
 

Ironside

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This is something new.

Do you have the source for this low LDL and stroke ?
  • While low LDL cholesterol generally reduces the risk of stroke, very low LDL levels (below 50-70 mg/dL) have been linked to an increased risk of hemorrhagic stroke, particularly in women. This means that while lowering LDL cholesterol is crucial for stroke prevention, the goal is to achieve optimal levels, not necessarily the absolute lowest possible.

    Elaboration:
    • Low LDL and Stroke Prevention:
      Low-density lipoprotein (LDL), often referred to as "bad" cholesterol, contributes to plaque buildup in arteries, increasing the risk of heart attacks and strokes. Lowering LDL cholesterol through diet, exercise, or medication is a key strategy to reduce stroke risk.

    • U-Shaped Relationship:
      Some studies suggest a U-shaped relationship between LDL levels and stroke risk. While lower LDL levels reduce ischemic stroke risk, very low LDL levels (below 70 mg/dL) may increase the risk of hemorrhagic stroke, also known as bleeding stroke.

    • Hemorrhagic Stroke:
      Hemorrhagic stroke occurs when a blood vessel in the brain ruptures and bleeds, causing damage to brain tissue. While less common than ischemic stroke (blood clot blocking blood flow), it can be more severe and life-threatening.

 
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